A big issue in the supplement world is whether the ingredient is synthetic or not synthetic (certified natural). If it is processed and not natural, our bodies actually need to work harder to consume it. Through this process, you can lose more energy. Or you can store some of the excess as toxins in your body.
This also relates to the extra fillers and preservatives that are found in lower quality supplements.
It turns out 90% of supplements out there are synthetic. This means when you see
studies or articles that show that people take supplements and there is no
difference or health improvement, there is a 90% chance they are taking
synthetics.